Simple Spectrophotometric Methods For Determination Of Ambroxol Hydrochloride From Pharmaceutical Formulation

Simple sensitive and accurate spectrophotometric methods have been developed for the estimation of ambroxol hydrochloride in pharmaceutical dosage form. The drug was diazotised with sodium nitrite in presence of acetic acid and then it was coupled with catechol or resorcinol or β-naphthol in alkaline medium. The resulting coloured chromogenic species in solution were directly measured at their maximum absorption at 425 nm respectively. The proposed methods were validated statistically. The linearity was found to be 1.0-16 μg/ml, 10-60 μg/ml, and 1.0-20 μg/ml for method I, II and III respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of ambroxol hydrochloride in tablets.